Assessment of serum afamin in patients with preeclampsia at third trimester

الملخص

Preeclampsia is a multisystem disorder that occurs during pregnancy and cause ten percent global a newborn and perinatal mortality and mortality [1]. Its mechanism is not readily apparent. Immunologic maladaptation of maternal antibodies to placental and fetal antigens, which may cause inflammation and lead to irregular placentation and placental hypoxia, is another possibility. Vascular sensitivity to angiotensin II is increased, and the production of vasodilators like nitric oxide is reduced which may lead to be the results of placental hypoxia [2]. Risk factors for preeclampsia include hypertension, obesity, nulliparity, chronic diabetes, adolescent pregnancy and conditions leading to hyper placentation and large placentas such as twin pregnancy, renal disease, previous preeclampsia, autoimmune diseases and pregnancies in multiples [3]. Preeclampsia is diagnosed after 20 weeks of gestation. The diagnosis depends on hypertension associated with proteinuria,“Hypertension: systolic blood pressure (SBP)