The objective of present study was to verify the changes of serum levels of ET-1 and VEGF in Chronic Renal Failure (CRF) Patients
undergoing haemodialysis. Sixty five of haemodialysis patients were enrolled in this study and compared with forty healthy subjects.
Thirty from these patients were followed up to six months for serial assessment of these biomarkers as well. The results indicated
significant elevations of VEGF and ET-1 levels when compared with the control group (P < 0.0001). Also the statistical analysis
showed a significant difference in serum levels of VEGF (P < 0.003) according to different causes of chronic renal failure while there
was no significant difference in serum levels of ET-1 within different etiology of haemodialysis patients. Moreover there was a
significant differences in 3rd and 4th reading of ET-1 and VEGF and a significant differences in 2nd reading of ET-1 level (P < 0.05) when
compared to first reading of VEGF and ET-1 through the period of serial assessment. Further, a significant negative correlation were
observed for ET-1 and VEGF levels with the GFR of patients(P < 0.05) and a significant positive correlation were demonstrated for
the level of ET-1 (P < 0.05) while not with VEGF when they have correlated with the duration of dialysis of patients. The results
pointed out that ET-1 and VEGF levels are involved in the pathophysiology of the disease and they were useful in the prediction of
the disease earlier to the clinical manifestations of atherosclerotic and cardiovascular disease.
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31-7-2015
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