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Serum Levels of Intercellular Adhesion Molecules, Vascular Cell Adhesion Molecules, and C - reactiveProtein in Chronic Renal Failure Patients Receiving Haemodialysis with Different Etiology
Authors :
The objective of present study was to verify the changes of serum levels of ICAM-1 and VCAM-1 in Chronic Renal Failure (CRF) Patients undergoing haemodialysis. Sixty five of haemodialysis patients were enrolled in this study and compared with forty apparently healthy subjects. Thirty from these patients were followed up to six months for serial assessment of these biomarkers as well. The results indicated significant elevations of ICAM-1 and VCAM-1 serum levels when compared with the control group (P < 0.001). Also the statistical analysis showed a significant difference in serum level of ICAM-1 and VCAM-1 within different etiology of hemodialysis patients (P < 0.001). Moreover there were significant differences in 4th reading of ICAM-1 and VCAM-1 and a significant difference in 3rd reading of VCAM-1 when compared to first reading of ICAM-1 and VCAM-1 serum levels through the period of serial assessment (P < 0.05). Further, a significant negative correlation was observed for ICAM-1 and VCAM-1 serum levels with the glomerular filtration rate GFR of patients and a significant positive correlation was demonstrated for the level of ICAM-1 and VCAM- 1 with the duration of dialysis (P < 0.05). The results pointed out that ICAM-1 and VCAM-1 levels are involved in the pathophysiology of the disease and they were useful in the prediction of the disease earlier to the clinical manifestations of atherosclerotic and cardiovascular disease. In addition the measurements of these biomarkers were significantly correlated with etiology of CKD, duration of dialysis and GFR in haemodialysis patients.

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31-7-2015