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Tolerable Ocular Hypotensive Effect of Topically Applied Sildenafil in Ocular in Normotensiveand Betamethasone-Induced Hypertensive Rabbits
Authors : Waleed K. Abdulsahib1, Adeeb Al-Zubaidy1 , Hayder B Sahib*2, Sarmed H. Kathem1
The study aimed to evaluate the effect of topical sildenafil drop on Intraocular Pressure (IOP) in rabbits of both normotensive and betamethasone-induced hypertensive eyes. 36 rabbits allocated into two groups: ocular normotensive and hypertensive group, each group further subdivided into 3 subgroups. Sildenafil ophthalmic solution (0.3%) was instilled twice daily for 7 days in normotensive and hypertensive subgroups, another two subgroups of both normotensive and hypertensive were used to evaluate the effect of timolol and distilled water (DW). Intraocular pressure IOP measured by Schiotz tonometer. Sildenafil was very effective in lowering IOP in both normotensive & ocular hypertensive rabbits. Mean IOP decreased after one day of sildenafil instillation (2.5 ± 0.56 mmHg) in normotensive eye and (1.3±0.61) in hypertensive eyes. A significant results (P≤0.05) were obtained when compare the results of sildenafil with DW; no significant differences were obtained with timolol group. Sildenafil ophthalmic solutions have the capability of IOP reduction and possible modulation of its regulatory mechanisms.

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31-10-2015.