The study aimed to evaluate the effect of topical sildenafil drop on Intraocular Pressure (IOP) in rabbits of both normotensive and
betamethasone-induced hypertensive eyes. 36 rabbits allocated into two groups: ocular normotensive and hypertensive group, each
group further subdivided into 3 subgroups. Sildenafil ophthalmic solution (0.3%) was instilled twice daily for 7 days in normotensive
and hypertensive subgroups, another two subgroups of both normotensive and hypertensive were used to evaluate the effect of
timolol and distilled water (DW). Intraocular pressure IOP measured by Schiotz tonometer. Sildenafil was very effective in lowering
IOP in both normotensive & ocular hypertensive rabbits. Mean IOP decreased after one day of sildenafil instillation (2.5 ± 0.56
mmHg) in normotensive eye and (1.3±0.61) in hypertensive eyes. A significant results (P≤0.05) were obtained when compare the
results of sildenafil with DW; no significant differences were obtained with timolol group. Sildenafil ophthalmic solutions have the
capability of IOP reduction and possible modulation of its regulatory mechanisms.
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31-10-2015.
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