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Infection with Hydatid Cyst can Predispose to Liver and Lung Cancers
قاسم شرهان حرج
Authors : Eman Salman Kamaes, Nagham Yassin Al-Bayati, Qasim Sh Al-Mayah, Nada M. Al-Bashier
Background: Infections are major causes of malignancies. Several parasitic agents are well documented in their association with different cancers. However, the causative relationship of many other parasitic agents with cancers are still a debate issue. Aim: The current study aimed to investigate the possible role of hydatid cyst (HC) in liver and lung cancers. Subject and Methods: A case /control study which involved 42 patients with HC, 35 patients with liver or lung cancer and 25 healthy control was conducted. Serum levels anti-Ehinococcus IgG antiboies, Carbohydrate antigen (CA19-9), caspase-8 and gamma glutamyltransferase (GGT) were determined by enzyme linked immunosorbent technique (ELISA) using commercial kits. Results: Eleven patients with liver or lung cancer (32.42%) gave positive result for anti-Echinococcus antibodies compared to one case (4%) among control (OR= 8.3, 95%CI=0.978-70.55). Hydatid cyst and cancer groups showed significantly higher serum levels of CA19-9 and GGT than control group, while caspase-8 levels declined in cancer group compared with that of HC and control group. Conclusion: These data suggest a possible role for HC as a carcinogenesis in liver and lung cancers.

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12/2015