The etiology of Nephrotic syndrome (NS) is unknown however various evidences
suggest that immune dysfunction play a key role in the pathogenesis of NS. This
study was established to investigate the role of IgE in the pathogenesis of NS, and
some immune mediators (IL-17A and TGF-β1). Fifty three patients with NS were
enrolled in the present study, aged from 2 to 17 years. Control group consist of 27
healthy children. Blood samples were collected from patients and controls to assess
serum levels of IgE, IL-17A and TGF-β1 by Enzyme-Linked Immunosorbant
Assay (ELISA). The level of both IgE and IL-17A was significantly higher in NS
patients than healthy control, and the level was higher in patients with resistant to
steroid than sensitive and in relapse phase than in remission phase and in patients
with history of allergy than those patients without history of allergy. Whereas the
level of TGF-β1 was lower in NS patients as compared with control and lower in
patients with relapse phase and newly diagnosed than in patients with remission
phase and lower in steroid resistant patients than steroid sensitive patients .While
the level of TGF-β1 was higher in patients with history than those without history
of allergy. Patients with NS exhibit increased serum level of IgE and this may be
related to sensitivity to steroid treatment. Moreover, IL-17A/TGF-β1ratio
imbalance may act as a potential factor in the pathogenesis of NS.
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june 10 2016
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