Objective: This study aims to evaluate the role of kisspeptin-10 in preeclampsia and check for possible
relationship between its severity and fetal growth well-being. Kisspeptin-10 may participate in implantation
of the embryo, placenta formation, and maintenance of pregnancy.
Materials and Methods: One hundred women who completed 20 weeks of gestation with singleton
pregnancies were divided into 60 peeclamptic and 40 normotensive control women. Kisspeptin-10 level
estimation, and ultrasound and Doppler ultrasound studies for umbilical artery were performed during
their second and third trimesters of pregnancy.
Results: Plasma kisspeptin-10 level was lower in preeclamptic groups and inversely correlated with the
severity of the disease. Its level directly correlated with estimated fetal weight in utero during both
trimesters in patients with severe preeclampsia and with fetal birth weight in patients with mild preeclampsia,
whereas an inverse correlation was observed in those with severe preeclampsia during their
second trimester. Kisspeptin-10 level was directly related to the resistance index in the second trimester
in patients with severe preeclampsia, while it inversely correlated with the systolic/diastolic ratio and
resistance index in the third trimester in patients with mild preeclampsia.
Conclusion: Kisspeptin-10 level is useful in assessing the severity of preeclampsia and can be a novel
marker downregulated in pregnant women with preeclampsia, especially in those who also developed
impaired uteroplacental perfusion or intrauterine growth restriction.
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December 2016
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