Background: Maternal accommodation to normal pregnancy begins shortly after conception,during pregnancy the anatomical and histological changes occur in the kidneyas a maternal adaptation for physiological changes. Aim: Evaluation morphological changes in the kidney glomeruli and tubules during pregnancy, Histomorphometrical assessment of glomeruli and tubular changes with pregnancy.
Material and Method: This study carried on 40 mature mice divided into two groups, 20 pregnant mice served as experimental group and 20 non-pregnant mice as a control group, kidneys were removed; the weight is measured and then fixed, dehydrated in ascending grades of alcohol, cleared in xylene and infiltrated with paraffin. The paraffin blocks were made and 5μm thin sections were obtained using a rotary microtome. The sections were stained with H&E stain, PAS examined under light microscope.
Result: Under the light microscope, the kidney in experimental group show the many anatomical changes as increase in Wight, elongated and increase in width, and showed many histological changes as a glomerular enlargement with decrease of urinary space and dilation in proximal and distal tubule. A statistically significant differences have been shown in the diameter of renal corpuscle, glomerular tuft and Bowman’s space, and also in the renal tubules proximal and distal convoluted tubules (p<0.001). And in Wight, elongation and width as (p<0.001).
Conclusion: The results of the present study indicated during pregnancy kidney undergo to anatomic change as increase in size and Wight, and histologic change as elongation in glomeruli, and dilation in diameter of tubule.
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January 2017
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