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Expression of c-Myc and BMI-1 in Iraqi glioma patients
حيدر أحمد شمران
Authors : - Shamran, H.A.; Hamza, S.J.; and Yaseen, N.Y.
Abstract Background: Gliomas are the most common adult brain tumor and are associated with high fatality rates. Despite substantial efforts, the etiology of this cancer remains poorly understood Gliomas are primary brain tumor accounting for about 80% of these tumors. Many environmental and inherited factors can have a role in the progression of these tumors. Aim: This study aimed to investigate the association of c-Myc and BMI-1 expression with incidence of glioma in Iraqi patients. Materials and Methods: Fifty paraffin-embedded tissues from glioma patients were used for immunohistochemistry study to evaluate the expression of c-Myc and BMI-1 proteins in these tissues. Monoclonal antibodies for these proteins were used, and the immunoreactive scores were calculated according to staining intensity and the percentage of tumor cells with nuclear staining. Results: Among the examined fifty samples, there were 36 cases of glioblastoma multiforme (GBM), and 14 cases of anaplastic astrocytoma. For GBM, 77.22% and 69.44% of samples were positive for c-Myc and BMI-1 proteins respectively, while 71.43% and 85.7% of anaplastic astrocytoma samples were positive for the two proteins respectively. There was a significance correlation in the expression of the two proteins. Conclusion: c-Myc and BMI-1 are highly expressed in glioma tumors and may be involved in the tumerigenesis of this malignancy.

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2014-8-1