Abstract
Background: Gliomas are the most common adult brain tumor and are
associated with high fatality rates. Despite substantial efforts, the etiology of
this cancer remains poorly understood Gliomas are primary brain tumor
accounting for about 80% of these tumors. Many environmental and
inherited factors can have a role in the progression of these tumors.
Aim: This study aimed to investigate the association of c-Myc and BMI-1
expression with incidence of glioma in Iraqi patients.
Materials and Methods: Fifty paraffin-embedded tissues from glioma
patients were used for immunohistochemistry study to evaluate the
expression of c-Myc and BMI-1 proteins in these tissues. Monoclonal
antibodies for these proteins were used, and the immunoreactive scores were
calculated according to staining intensity and the percentage of tumor cells
with nuclear staining.
Results: Among the examined fifty samples, there were 36 cases of
glioblastoma multiforme (GBM), and 14 cases of anaplastic astrocytoma. For
GBM, 77.22% and 69.44% of samples were positive for c-Myc and BMI-1
proteins respectively, while 71.43% and 85.7% of anaplastic astrocytoma
samples were positive for the two proteins respectively. There was a
significance correlation in the expression of the two proteins.
Conclusion: c-Myc and BMI-1 are highly expressed in glioma tumors and
may be involved in the tumerigenesis of this malignancy.
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2014-8-1
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