اختيار اللغة
وحدة البحوث الطبية العلاقات الثقافية شعبة ضمان الجودة و الأداء الجامعي وحدة التعليم الطبي و تطوير المناهج الدراسية لجنة التعضيد شعبة النشاطات الطلابية
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THE EVALUATION OF HISTOLOGICAL CHANGES AND IMUNOHISTOCHEMICAL EXPRESSION OF AMYLOID PRECURSOR PROTEIN IN CEREBRAL AND CEREBELLAR CORTICES IN NEWBORN MICE AFTER PRENATAL EXPOSURE TO TRAMADOL
هدى رشيد كريم
Authors : Thair M. Farhan, assistant prof. Huda R. Kammona* and prof. Haider J. Mubarak* Anatomy Department, Histology and Embryology Section, Al-Nahrain College of Medicine.
Tramadol is a centrally acting analgesic used to relief moderate to severe pain, its use in pregnancy is generally avoided, little information available on its effect on the central nervous system if taken during pregnancy. Amyloid precursor protein (APP) is expressed in many tissues including neurons, it play a major role in neuronal survival, synapse formation, and neuronal growth. This study implicated to demonstrate the changes in APP expression in cerebral and cerebellar cortices upon prenatal exposure to different doses of tramadol. A sample of 60 pregnant mice were divided into four groups, control group that received D.W daily intra peritoneally, and test groups subdivided accordingly to 40,60, and 80mg/kg of tramadol daily intra peritoneally from the start of pregnancy. Cerebral and cerebellar cortices of one day postnatal mice were prepared for paraffin sections for H & E, and anti- APP immunohistochemistry . Significant changes in histological features were seen include cerebral and cerebellar atrophy, vascular changes , apoptotic changes, also changes in choroid plexus of the 4th ventricle. APP expression showed significant changes among groups. These findings indicate the harmful effect of prenatal tramadol treatment on the cerebral and cerebellar development specifically at higher doses, and the increase in APP expression t is proportional to the dose of treatment in a way to protect neuronal tissue and to trigger apoptosis.

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23-44/2017(wjpr,6(14