اختيار اللغة
وحدة البحوث الطبية العلاقات الثقافية شعبة ضمان الجودة و الأداء الجامعي وحدة التعليم الطبي و تطوير المناهج الدراسية لجنة التعضيد شعبة النشاطات الطلابية
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Serotonin and serotonin transporter levels in autistic children
عمر فاروق عبد الرشيد
Authors : Haidar A. Abdulamir, Omar F. Abdul- Rasheed, Emad A. Abdulghani
Objectives: To assess the possible correlation between serotonin and serotonin transporter (SERT) with the autism severity and investigate the association between these parameters in autistic children to assess their possible role for diagnosis of autism severity. Methods: A comparative cross- sectional study was done in the Chemistry and Biochemistry Department, College of Medicine, Al-Nahrain University, Baghdad, Iraq while the samples were taken from 60 male autistic children recruited to the Department of Paediatrics at Al-Sader Hospital, Baghdad, Iraq in the period from November 2014 to April 2015. Levels of SERT and serotonin were determined in 60 male autistic Iraqi patients classified into mild, moderate and severe (20 for each). These levels were compared with those of twenty-six healthy control children. Results: levels of serotonin and SERT were significantly increased in autistic children than that of gender and age-matched controls. Serotonin levels were 80.63± 21.83 ng/ml, 100.39±23.07 ng/ml and 188.7±31.72 ng/ml in mild, moderate and severe autistic patients, respectively. SERT levels were 10.13±4.51 ng/ml, 13.15±4.71 ng/ml and 16.32±6.7 ng/ml in mild, moderate and severe autistic patients, respectively. The increase of both serotonin and SERT levels were associated with severity of autism. Receiver operating characteristic (ROC) analysis and also demonstrated that these parameters can be used for diagnostic and prognostic purposes. Conclusions: High serotonin and SERT levels may indicate that these biomarkers have a role in the autism pathogenesis and support the possibility of using serotonin and SERT to diagnose autism severity.

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1/05/2018