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Trichomonas vaginalis infection as a risk factor for prostate cancer
قاسم شرهان حرج
Authors : International Journal of Current Microbiology and Applied Sciences
Infection plays a role in the pathogenesis of many human malignancies. Prostate cancer (PCa) is an important health problem in men worldwide. Trichomonas vaginalis infection is the most common non-viral sexually transmitted infection which can cause chronic prostatitis in infected men. This study aimed to investigate the assumption of T. vaginalis infection as a risk factor for PCa. Serum samples from 50 confirmed PCa patients and 40 healthy control were analyzed by means of enzyme-linked immunosorbent assay for the presence of ant-trichomonas IgG antibodies. In addition, DNA was extracted from 23 paraffin-embedded prostate tissue samples referred to the PCa patients. The extracted DNA was used for detection of hypothesized T. vaginalis nucleic acid by polymerase chain reaction technique using specific primers designed for this purpose. There was positive non- significant association between ant-trichomonas IgG antibodies and PCa (p=0.047, Odds ratio=3.895, 95% CI=1.016-14.929). No evidence for T. vaginalis nucleic acid with the host genome was observed. T. vaginalis may increase the risk of PCa when there is prolonged infection within the prostate.

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November 2013