اختيار اللغة
وحدة البحوث الطبية العلاقات الثقافية شعبة ضمان الجودة و الأداء الجامعي وحدة التعليم الطبي و تطوير المناهج الدراسية لجنة التعضيد شعبة النشاطات الطلابية
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Role of Il-17 in Toxoplasma Lymphadenitis
هدى ظاهر هذال
Authors : Jabbar S. Hassan1, Hadeel J. Rashied and ThairM. Wali
Toxoplasmosis is the general term for infection and disease in man and animal caused by a parasite called Toxoplasma gondii. There are six members in the IL-17 cytokine family, including IL-17A (commonly referred to as IL-17).In Toxoplasmosis the role of IL-17 was involved in the development and early recruitment of neutrophils, which are essential to clear the parasites during initial stages of infection. This study was carried out to diagnosis the Toxoplasma lymphadenitis and to determine the role of IL-17 in this disease. A total of 45 lymph node tissue samples (paraffin block) were enrolled in this study. Three sections were made from the paraffin-embedded tissue blocks, one section for H&E staining. Two sections were processed by immunohistochemistry (IHC) procedure. The first for diagnosis Toxoplasma antigen (P30) while the second section for diagnosis IL-17byusing specific immunohistochemistry (IHC) detection kits. From 45 patients who examined by H&E, only 25 patients had evidence of Toxoplasma. The lymph nodes with histological evidence of Toxoplasmosis showed positive Immunohistochemical Toxoplasma antigen expression, but, neither reactive lymph nodes nor normal ones showed positive immunohistochemical Toxoplasma antigen expression. Immunohistochemical expression of IL-17 was assessed by two methods. The first one is represented by the percentage of inflammatory cells that express the marker IL-17, and the second method is named "IL-17 score" In this study we concluded there are highly significant expressions in levels of IL-17 by immunohistochemistry assay in both the percent and score methodswhich can give an idea about the association between IL-17 and toxoplasma lymphadenitis.

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Int.J.Curr.Microbiol.App.Sci (2015) 4(12): 142-150