ABSTRACT
The aim of the study was to assess the effect of sitagliptin on atherosclerosis via interfering with inflammatory and oxidative
pathways. Twenty four local domestic male rabbits were involved in this study. The animals were randomly divided into three groups, Group I rabbits fed normal chow (oxiod) diet for 12 weeks. Group II rabbits fed with 1% cholesterol enriched diet. Group III rabbits fed with 1% cholesterol enriched diet together with sitagliptin (10 mg/kg once daily before morning feed). Blood samples were collected before (0 time) and every four weeks of experimental diets for measurement of serum triglycerides, total cholesterol, high density lipoprotein cholesterol, high sensitive C-Reactive Protein, endothelin-1 and intracellular adhesion molecule-1 level. At the end of 12 weeks the aorta was removed for measurement of aortic Malondialdehyde, reduced glutathione and aortic intimal thickness. Sitagliptin treatment did show a non significant effect on lipid parameters compared with induced untreated group (P > 0.05). It was significantly reduced the elevation in high sensitive C-Reactive Protein, endothelin-1, intracellular adhesion molecule-1 level, aortic MDA and aortic intimal thickness compared with induced untreated group (P < 0.05), and they restore aortic reduced glutathione level (P < 0.05). Sitagliptin may reduce atherosclerosis progression in hyper cholesterolemic rabbit via interfering with inflammatory and oxidative pathways without affecting lipid parameters.
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20-11-2014
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