Objective: Endothelin1 (ET1) is 21- amino acid vasoconstrictor peptide secreted by endotheliumwhich has an
important role in the pathoohysiology of preeclampsia (PE). The objective of this study was to evaluate the binding
sites and quantitative changes in ET1 in umbilical cord vessels of PE patients.
Methods: This study recruited 40 pregnant women between 20-40 years old at 3rd trimester. All cases selected for
this study underwent an elective cesarean section, grouped into 2 groups; PE group of 20 pregnant women (at 3rd
trimester) who proved to have pregnancy induced hypertension and proteinuria. The control group was of 20 healthy
pregnant females at the same average of gestational age and with the same exclusion criteria and no PE, underwent
elective caesarean section. Umbilical cord tissues were taken from the maternal side, fixed with formalin, paraffin,
embedded sections of umbilical cord were treated with Endothelin1 antibody. The immunoreactivity of ET1 was
assessed using Aperio image scope software. Statistical analysis was done using SPSS program.
Results: The results demonstrated a significant increase (P = 0.001) of ET1 expression in cord vessels of PE group
with respect to control group (mean 28.5±1.7, 2.6±0.4 respectively).
Conclusion: It is concluded that ET1 is markedly increase in PE and may be the cause behind promoted vascular
smooth muscle cell contraction and blood pressure elevation in PE.
Keywords: Endothelin1; preeclampsia; pregnancy; umbilical cord (Siriraj Med J 2020; 72: 167-173)
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mrach 2020
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