Background: Chronic inflammatory demyelinating polyneuropathy (CIDP)
is characterized by progressive or relapsing motor or sensory symptoms,
with variants differing in the relative distribution of these symptoms and
electrophysiologic findings. We aimed to correlate the electrodiagnostic patterns
of demyelination using Hughes Functional Grading Scale in patients with CIDP.
Methods: A case–control study was conducted at the neurophysiology department
of Al‑Imamian Al‑Kadhymian Medical city and Nursing Home Hospital, Medical
City, Baghdad from December 2017 to June 2018. Fifteen patients with CIDP
aged 30–60 years with disease duration between 6 months and 2 years and 20
age‑matched healthy subjects (control group) were included in the study. The
participants were submitted to medical history, clinical neurological examination,
and electrophysiologic tests. Results: Patients with CIDP demonstrated prolonged
distal sensory and motor latencies, decreased sensory nerve action potential
amplitude, slowing of sensory and motor nerve conduction velocity, and prolonged
mean F‑wave latency. The majority showed absent sural sensory responses.
Significant relationships were demonstrated between the Hughes Functional
Grading Scale and different neurophysiologic parameters, and no correlation was
found with the terminal latency index. Conclusions: Patients with high Hughes
functional scoring also have severe abnormalities in motor parameters, usually in
the range of demyelination. The involvement of nerve segments was multifocal
affecting mostly the proximal and intermediate nerve segments; the terminal
segments were involved to a lesser extent.
Keywords: CIDP, Hughes Functional Grading Scale, terminal latency index
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29 June 2020
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