Effect of Metformin on Adenosine Deaminase Activity in Polycystic Ovarian Syndrome patients
فيصل غازي جاسم
Authors : Faisal Gh. Al-Rubaye*, Taha Shawi Morad **, Maysoon A. Ahmed ** *Department of Chemistry & Biochemistry, College of Medicine, Al-Nahrain University **Department of Medical Biology, College of Medicine, Al-Nahrain University
Abstract This study was done to assess the role of adenosine deaminase (ADA) in women with polycystic ovarian syndrome (PCOS) on metformin therapy. The present study is a cross-sectional study (2011/2012) at Al-yarmouk teaching hospital. A total of 80 patients with PCOS were involved in this study, they were classified as newly diagnosed women with PCOS G1: (n=40);women with PCOS on metformin therapy 500 mg (bid) for 90 days G2: (n=40). A matching group of forty apparently healthy women who were included as controls(n=40). Serum ADA was measured in all women and it was significantly reduced in women with PCOS receiving metformin therapy when compared with newly diagnosed patients with PC (p < 0.001) also a significant reduction was found when controls compared with the newly diagnosed women (p < 0.001); however, the reduction was insignificant when controls compared with treated group (p < 0.05). In conclusion,the results of this study suggest that the metformin currently used by PCOS patients has indirect effect on ADA activity through improving insulin sensitivity

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