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Regional Variation in Tunel and BCL-2 Expression in the Trophoblastic Tissue of Normal Human Placenta with Aging and Estimation of the True Apoptotic Index Ratio
علاء غني حسين مبارك
Authors : by Huda. R.Kareem, Alaa. G.Hussain, Haider. A.Jaafa, Iraq.
This study aimed to evaluate the Tunel and BCL-2 expression in syncytiotrophoblast and true apoptotic index ratio in preterm. Term, and postdate placenta in different placental regions (cord insertion, central and peripheral) were done. A significant variation in the number of Tunel stained positive cells at P≤0.05 was evident among age groups in cord insertion and peripheral region of placenta, and a significant variations in the number of BCL-2 stained cells at P≤0.05among groups were evident in all regions in preterm placenta. The apoptotic index ratio was evidently increased with aging in all placental regions. A significant positive correlations was found between Tunel stained positive cells and BCL-2 positive cells in postdate group in cord insertion region at r. 0.472, preterm group in central region at r.0.601, and a significant negative correlation was found in postdate group in peripheral region at r.0.57. These results indicated that Tunel and BCL-2 showed various modes of expression in syncytium in different placental regions with aging, and the apoptotic index ratio represent the true measure of apoptosis, this emphasize the importance of apoptosis in permitting normal physiological turnover of villous trophoblast and also exhibits the contribution of BCL-2 in maintaining syncitial integrity throughout normal pregnancy.

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1-4-2015