ABSTRACT
Nephroprotective effect of aqueous thyme extract was investigated in rabbits with acute renal injury
induced by a single i.p.
injection of cisplatin (6.5 mg/kg). Aqueous thyme extract treatment (500 mg/kg/day, orally) was appl
ied for 7 consecutive day
s,
starting 4 days before cisplatin administration. Aqueous thyme extract significantly reduced serum u
rea and serum creatinine
lev
els
and increased serum albumin levels which were altered by cisplatin. Aqueous thyme extract significan
tly compensated deficits
in
kidney tissue glutathione level, suppressed lipid peroxidation, and decreased the elevations of seru
m tumor necrosis factor
-
alpha
resulted from cisplatin administration. Also, histopathological renal tissue damage mediated by cisp
latin
as well as inflammatory
cells infiltration was
greatly ameliorated by aqueous thyme extract treatment. It was concluded that aqueous thyme extra
ct
represents a potential therapeutic option to protect against acute cisplatin nephrotoxicity commonly
encountered in clinical
practice.
Keywords:
Aq
ueous Thyme Extract, Cisplatin,
Induced Nephrotoxicity in Rabbits
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January – February 2015
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