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Effects of Aqueous Thyme Extract against Cisplatin Induced Nephrotoxicity in Rabbits
بان جمعة قاسم
Authors : Ahmed Rhahma Abu-Raghif, Ban J Qasim, Ali Husseain Abady, Hayder B Sahib
ABSTRACT Nephroprotective effect of aqueous thyme extract was investigated in rabbits with acute renal injury induced by a single i.p. injection of cisplatin (6.5 mg/kg). Aqueous thyme extract treatment (500 mg/kg/day, orally) was appl ied for 7 consecutive day s, starting 4 days before cisplatin administration. Aqueous thyme extract significantly reduced serum u rea and serum creatinine lev els and increased serum albumin levels which were altered by cisplatin. Aqueous thyme extract significan tly compensated deficits in kidney tissue glutathione level, suppressed lipid peroxidation, and decreased the elevations of seru m tumor necrosis factor - alpha resulted from cisplatin administration. Also, histopathological renal tissue damage mediated by cisp latin as well as inflammatory cells infiltration was greatly ameliorated by aqueous thyme extract treatment. It was concluded that aqueous thyme extra ct represents a potential therapeutic option to protect against acute cisplatin nephrotoxicity commonly encountered in clinical practice. Keywords: Aq ueous Thyme Extract, Cisplatin, Induced Nephrotoxicity in Rabbits

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January – February 2015