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CD10 and CA19.9 immunohistochemical expression in transitional cell carcinoma of the urinary bladder
بان جمعة قاسم
Authors : Ahmed Salahaldeen Mohammed و Husam Hasson Ali , Ban Jumaa Qasim, Mohammed Kassim Chaloob
Background: Transitional cell carcinoma of the bladder is the most common malignancy affecting the urinary tract ranking the 5th most common cancer in males and the 9th most common cancer in females in Iraq. The prognosis depends largely on the histologic grade of the tumor and the stage at diagnosis, however, there is no reliable parameter predicting the risk of recurrence or progression, therefore; molecular and immunological markers are required to estimate the individual prognosis of patients as well as for effective diagnosis and treatment. Objectives: To evaluate CD10 and CA19.9 immunohistochemical expressions in transitional cell carcinoma of the urinary bladder and to correlate these expressions grade and stage of the tumor. Methods: This study was retrospectively designed. Forty nine cystoscopy specimens of urothelial carcinoma of the bladder were retrieved from the archival materials of the Specialized Surgical Hospital and Al-Khadhmiya Teaching Hospital in Baghdad for the period from January 2010 to June 2011. Three sections of 5µm thickness were taken from each case. One section was stained with Hematoxylin and Eosin; the other two were stained immunohistochemically with CA19.9 and CD10. Results: Immunohistochemical expression of CA19.9 and CD10 had a significant correlation with WHO 2004 grade of urothelial carcinoma. There was no significant correlation between CA19.9 and CD10 immunohistochemical expression with stage. Conclusions: CA19.9 and CD10 immunohistochemical expression could be of valuable significance in assisting the differentiation between high and low grade urothelial carcinoma cases and consequently in determining the prognosis in such cases. Key words: transitional cell carcinoma, urinary bladder, CA19.9, CD10

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2014