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Retinol binding protein- 4 and insulin resistance in obese patients with type 2 diabetes mellitus treated with oral antidiabetic agents at Baghdad city
عمر فاروق عبد الرشيد
Authors : Anas H. Sadek , Omar F. Abdul-Rashed, Mahmood S.Khudhair
Background: Type2 diabetes mellitus (T2DM) affects a large population (about 387 million people) worldwide and expected to increase by approximately 70% in the next 20 years. Adipose tissue is responsible for releasing various adipokines which have been related to insulin resistance. Retinol binding protein -4 (RBP-4) is one of these adipokine. Objective: To detect the relation between insulin resistance and serum retinol binding protein -4 (RBP-4) in type 2 diabetic obese patients at Baghdad city. Method: A case- control study was performed at Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq from March 2013 to August 2013. Forty five obese type 2 diabetic patients with mean body mass index (36.62± 0.8 kg/ m2) compared to forty obese age matched apparently healthy control subjects with no family history of type 2 diabetes. Laboratory and anthropometric measurements including: fasting plasma glucose, glycosylated hemoglobin, lipid profile, urea, creatinine, insulin, retinol binding protein-4, body mass index and waist to hip ratio were measured. Results: Serum retinol binding protein-4 (RBP 4) was significantly (p < 0.001) elevated in patients with type 2 diabetes mellitus (427.28 ± 23.28 µg/dl) compared with that in control group (244.19 ± 16.63 µg/dl). Fasting glucose (F.P.G), Glycosylated hemoglobin (HbA1c), were significantly greater in subjects with diabetes (p value for F.P.G and HbA1c). Whereas insulin and homeostatic model assessment of insulin resistance (HOMA-IR) showed no significant difference between patients and control group. Conclusion: Although serum RBP4 concentration was significantly increased in T2DM, but there is no significant association between RBP4 levels and the insulin resistance in obese type 2 diabetic patients.

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1/9/2015