ABSTRACT : Bone losses are main problems in many dental and medical specialties and may occur due to several physiologic and pathologic conditions. Bone tissue has enormous regenerating capacity and most of the time it is able to restore its usual architecture and mechanical properties. The total animals (24 male rabbits rabbit 30-35 weeks of age and weighing 2±0.5 Kg) were divided into 2 groups control and treated, both groups subdivided into three groups for each healing interval (A, B and C weeks), Group A: The samples collected after 2 weeks from tooth extraction, Group B: The samples collected after 4 weeks from tooth extraction, Group C: The samples collected after 6 weeks from tooth extraction. The surgical procedure includes extraction one lower anterior tooth (incisor) for all animals and then insertion of xenograft in the extracted tooth socket for only the treated groups. Animal’s sacrifices were done at 2, 4 and 6 weeks durations. Routine processing and sectioning technique performed on all bone specimens for Immunohistochemical analysis.Immunohistochemical analysis was utilized to quantify the expression of antiperiostin antibody for both treated and control groups in each durations. Immunohistochemical findings revealed high significant differences of positive expression of antiperiostin antibody at 6 weeks for mandible among the studied groups. The study revealed that application of xenograft was more effective in enhancement of bone regeneration and in acceleration of early bone healing process in treated groups as compared to the controlled one for future placement of dental implant.
Key words : Xenograft, antiperiostin, immunhistochemical.
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