The success rate of in vitro fertilization is still less than 40%. In implantation process, immunological mechanisms within the endometrium are very important and vital. Granulocyte-colony stimulating factor may play a crucial role in success of human reproduction by influencing implantation.
To evaluate the role of granulocyte-colony stimulating factor on pregnancy rate and endometrial receptivity by observing its effect on VEGF, TGF, Estradiol, progesterone and ultrasound Doppler Findings as endometrial thickness, pulsatile index, resistance index, V1/V2 and Zones.
A randomized clinical trial study conducted at the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University for a period of two years from 1st Sep. 2018 to 1st Sep. 2020. It included 40 women complaining from infertility with or without previous failure trial of Intracytoplasmic Sperm Injection and managed to undergo IVF / ICSI protocols reaching the day of embryo transfer with grade 1 (G1) embryos and received granulocyte-colony stimulating factor endometrial perfusion 6-12 hours before hCG trigger.
In this study, progesterone, VEGF, estradiol, endometrial thickness, RI, PI, V1/V2, zone and TGF were significantly improved at day of OPU compared to that at day of hCG. Pregnancy rate was 47.5%.
Granulocyte-colony stimulating factor has the potential to improve chemical and clinical parameters of the infertile females. This reflects increasing implantation rate, biochemical and clinical pregnancy rate.
Keywords: G-CSF, infertility, pregnancy rate, IVF, Iraq.
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2021 • vol.2 •
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