Abstract---The aim of this study is to investigate the antihyperlipidimic effect of Terpenes fraction of Iraqi Cicer areitinum in high-fat diet (HFD)-fed mice. Animals were divided into four groups (n =8). The total duration of the study was 56 days split into two intervals. During the first 28-days interval, mice were administered with HFD, whereas during the second 28-days interval they were co-administered HFD plus Terpenes (500mg/kg: p.o.) or the standard drug Atorvastatin (10mg/kg:p.o.). Terpenes treatment to HFD-induced hyperlipidemic mice caused a high significant decrement in the levels of total cholesterol, triglycerides, LDL-C and VLDL-C. Moreover, Terpenes resulted in significant increase in the levels of HDL-C, whereas it caused remarkable decreases in ALT, AST and ALP enzymatic activities also in total serum bilirubin levels among hyperlipidemic mice. Besides that, Terpenes treatment showed significant improvement in levels of tissue MDA and GSH in hyperlipidemic mice. Histopathological examination of hyperlipidemic mice showed a disorganized hepatic tissue, marked and diffused cytoplasmic fatty infiltration which was all ameliorated by Terpenes administration. The results revealed that Terpenes (500mg/kg;p.o.) possess potential ameliorating benefits against hyperlipidemia induced by HFD on lipid profile, liver function enzymes, oxidative stress parameters and hepatic histo-architecture. Further investigations are recommended and clinical trials are warranted to assess the efficacy and to fully dissect the mode of action underpinning the observed anti-hyperlipidemic effect of Terpenes.
Keywords---Hyperlipidemic, Cicer areitinum, Terpenes, lipid profile, Oxidative stress parameters.
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2022
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