Background: Reproductive failure is a significant public health concern. Although relatively little is known about
factors affecting fertility, a growing body of literature suggests that environmental & lifestyle factors play an important
role. Recent studies suggest that vitamin D may play a role in human reproduction. Exact mechanisms whereby vitamin
D may participate in the regulation of reproductive physiology remains far from clear.
Objective: To validate the potential of vitamin D as a biomarker for prediction of female infertility and to study the
correlation between vitamin D and Anti- Mullerian hormone.
Methods: A case- control study was conducted at Department of Chemistry and Biochemistry, College of Medicine,
Al- Nahrain University, Al- Kadhmiya, Baghdad, Iraq from June 2013 till July 2014. Seventy three subjects were
enrolled in this study. Thirty five primary infertile women with mean age (25.4± 4.91 years), and thirty eight agematched apparently healthy women as controls with mean age (27.3±3.72 years). Fasting blood samples were collected
in the morning at 8:00 am from all participants. Vitamin D was measured by high-performance liquid chromatography
technique and Anti- Mullerian hormone was measured by enzyme- linked immunosorbent assay.
Results: Vitamin D levels was significantly decreased in the infertile women group compared with fertile control group
(35.38±5.83 ng/ mL) versus (49.99±12.90 ng/ mL) respectively. Vitamin D correlated significantly (r = +0.86; p ≤ 0.05)
with anti-mullerian hormone and anti- mullerian hormone shows a significant negative correlation with body mass
index (r = -0.78; p ≤ 0.05).
Conclusion: A novel relationship was found between circulating Anti- Mullerian hormone and vitamin D in plasma
samples of infertile women
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2015
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