Polycystic Ovarian Syndrome (PCOS) is a common disorder affecting up to 21% of women of childbearing age, thought to be primarily a reproductive disorder.
Objective
To evaluate free testosterone, glucose. Total cholesterol, triglyceride, liver enzymes, thyroid hormones and prolactin in overweight PCOS Iraqi women compared with healthy lean women as a control group.
Materials and Methods
This was a case-control study carried in Al-Imamaien Al-Kathumain hospital, Baghdad, Iraq; between June 2014 and December 2015. The study included 75 female patients suffering from PCOS. The age of involved patients was 22-44 years (32.610±5.696 years). Control group was consisted of 30 healthy volunteer females, whose mean ages were matched (30.140±5.198 years).
Results
Our data showed that PCOS overweight women with general clinical signs of hyperandrogenism tended to have a higher BMI than healthy lean women 26.8±4.6 (kg/m2) P< 0.05, and total testosterone showed significant elevation 2.08±0.68 (nmol/L) P< 0.05. Our data showed there were a significant increase in mean±SD of serum level of glucose 95.00±12.7 (mg/dl), total cholesterol 187.0±50(mg/dl), triglyceride 79.5±30.5 (mg/dl) p< 0.001 respectively, AST 19.14±8.5 (U/L), ALT 16.22±4.5(U/L) p< 0.05, TSH 3.4±1.2 μIU/ml, T4 9.5±2.5 μg/dl, T3 2.6±0.8 ng/ml p< 0.01 and prolactin 27.00±4.5 ng/ml p< 0.001 in women with polycystic ovarian syndrome compared with healthy women.
Discussion
In adult women with hirsutism and PCOS, obesity is associated with increased total testosterone and decreased SHBG, which results in significantly elevated free and …
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2017/1
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