Defense of the Master's thesis by student Sally Iyad Abdul Khaleq.

The Master's thesis defense by student Sally Iyad Abdul Khaleq from the Department of Pharmacology was completed for her thesis titled:
**"Effects of Topical Ivermectin and Topical Myricetin on Imiquimod-Induced Psoriasis in Mouse Model."**
The aim of this study was to investigate the potential anti-psoriatic effects of the antibiotic ivermectin and the phenolic extract myricetin in experimental mice, based on observational and pathological anatomical results and biomarkers. The study showed that topical ivermectin and myricetin, as well as their combination therapy, significantly reduced inflammatory markers of psoriasis-like lesions, supported by histopathological examination. Topical ivermectin significantly reduced levels of vascular endothelial growth factor (VEGF). At the same time, the combination of ivermectin with clobetasol showed a more significant reduction in tumor necrosis factor-alpha (TNF-ɑ) and interleukin-17 (IL-17) levels. Concerning interleukin-10 (IL-10) levels, the combination of ivermectin and clobetasol showed a significant increase in IL-10 levels. The topical combination of myricetin with clobetasol also showed a notable increase in IL-10 levels and a significant reduction in TNF-ɑ, VEGF, and IL-17 levels.

The current study supports the following conclusions: Topical ivermectin and myricetin have anti-psoriatic activity and increase IL-10 levels. They can be successfully used to alleviate psoriasis symptoms, and further studies on inflammatory skin diseases are recommended. Combination therapy with clobetasol also showed excellent results in improving imiquimod-induced psoriasis in mice.

The defense committee consisted of:
- Professor Dr. Haitham Mahmoud Kazem (Chair)
- Professor Dr. Iqbal Ghaleb Farhoud (Member)
- Professor Dr. Mohammed Qasim Yahya (Member)
- Professor Dr. Fouad Kazem Kati (Supervisor)

The thesis was successfully accepted with honors.