Ulcerative colitis is a chronic, intermittent illness. The current treatment failed to cure the disease which made a need to investigate another drug with minimal side effects. The present research was conducted to assess the antioxidant and anti-inflammatory effects of ambrisentan in comparison with that of sulfasalazine in experimental colitis in rats. Acetic acid 4% (vol/vol) was used rectally to induce experimental colitis in rats. After induction, rats were administered either sulfasalazine 100mg/kg or ambrisentan 5 mg/kg orally for one week. There was the estimation of histopathological and macroscopical parameters also the expression of cytokines (TNF-α and IL-4), oxidative stress markers, malondialdehyde (MDA) and myeloperoxidase (MPO), and adhesion molecules (ICAM-1and ESelectin) in the colonic tissue. Both ambrisentan and sulfasalazine significantly reduced the macroscopical and histological injury in the colon induced by acetic acid. In addition to the downregulation of the increased colonic proinflammatory cytokines, MDA, MPO parameters and adhesive molecules. In conclusion: Ambrisentan had an effective role in experimental colitis in rats through anti-inflammatory and antioxidant actions with downregulation of the colonic adhesive molecule.
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2020/12
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