Abstract
Background Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder affecting
women of reproductive age characterized by multiple hormonal imbalances, reflecting on a clinical
presentation dominated by manifestations of hyperandrogenism, which generate short and long
term consequences on female health. Skin is a major target for androgen activity, several
hyperandrogenemia-triggered dermatologic alterations can be seen in PCOS, most commonly
hirsutism, androgenic alopecia, acne, seborrhea, onycholysis, and onychorrhexis. Zinc is one of the
most important trace elements required as a catalytic, structural, and regulatory ion for the
activities of more than 300 enzymes, proteins, and transcriptional factors. Zinc insufficiency in the
female can lead to complications such as impaired synthesis/secretion of follicular stimulating
hormone (FSH) and luteinizing hormone (LH), abnormal ovarian development.
Objective To assess serum zinc level in patients with PCOS.
Methods A case-controlled study was conducted in Al-Imamein Al-Kadhemein Medical City from the period
of March to June 2016. Eighty females were enrolled in this study; their age ranged from 20 to 32
years. They were divided into 4 groups: Group I: Twenty patients with PCOS with body mass index
(BMI) ranged from 30.0-40.0. Group II: Twenty normal healthy control obese ladies with BMI
ranged from 30.0-40.0. Group III: Twenty patients with polycystic ovary syndrome with BMI ranged
from 18.5-29.9. Group IV: Twenty females as a healthy control non-obese ladies with BMI ranged
from 18.5-29.9.
Results Serum zinc level was significantly decreased in obese PCO group than in non-obese PCO group.
Serum prolactin (PRL) level and LH levels were elevated in PCO group which was highly significant.
There was negative correlation between serum zinc level and BMI in PCO patients. Also, negative
correlation was observed between serum zinc level and serum PRL level in non-obese PCO patients.
Conclusion Serum zinc level reduced in obese PCOS than in non-obese PCO.
Keywords Serum zinc level, polycystic ovary syndrome
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2017
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