Retinal pathologic angiogenesis is the leading cause of blindness in human generate from age-related macular degeneration (AMD), diabetic retinopathy and premature retinopathy (ROP).The aim of this study is to investigate the effect of vitex agnus castus leave extract on induced retinal angiogenesis in rabbits by intravitreal injection of VEGF. Alcoholic extract of vitex agnus castus prepared and formulated for intravitreal injection. Twenty four pigmented rabbits included in this study and allocated into four equal groups(6 rabbits in each group): Retinal angiogenesis induced group, group treated by bevacizumab, group treated by 100mcg of Vitex agnus castus leave extract, and group treated by 50mcg of Vitex agnus castus leave extract as intravitreal injection. Parameters include matrixmetalloproteinase-9, intracellular adhesion molecule-1. The result of the current study revealed that intravitreal injection of Vitex agnus castus leave extract was reduced the level of MMP-9 and ICAM-1 in comparison with retinal angiogenesis induced group after one week of retinal angiogenesis induction, although it was non-significant (P>0.05).
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2021/7/1
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