The master's thesis defense of the student (Nabaa Yahya Khalil) in the Department of Physiology / Medical Physics at the College of Medicine, Al-Nahrain University.

“Study the Effect of Copper Oxide Nanoparticles on the Histological, Histomorphometrical, and Immunohistochemical Expression of Cadherin in the Kidneys of Male Mice.”

Conclusions:

The renal tissue and interstitial spaces showed congested blood vessels due to CuO nanoparticles, which stimulated lymphocytic infiltration of immune cells (lymphocytes and monocytes such as macrophages) into the kidney tissue. The toxic effects of CuO nanoparticles on kidney tissue led to apoptosis. Higher doses of CuO nanoparticles revealed an increase in the expression of E-cadherin proteins, indicating that copper has an affinity for E-cadherin. The toxicity of CuO nanoparticles in mouse kidney tissue was attributed to their size (38–50 nm in diameter), which may obstruct or affect the filtration slit diaphragm in the renal glomeruli, causing impairment of glomerular filtration, although the slit diaphragm typically ranges from 30–40 nm in width.

Prof. Dr. Hussein Saleh Hassan – Chair

Asst. Prof. Dr. Huda Rasheed Kareem – Member

Asst. Prof. Dr. Jenan Hussein Taha – Member

Asst. Prof. Dr. Mazen Kamel Hamed – Member and Supervisor

Prof. Dr. Haider Abdulrasool Jafar – Member and Supervisor

The thesis was accepted with a grade of Excellent.