Doctoral Dissertation Explores the Role of Oxidative Stress Biomarkers in Diabetic Cardiovascular Complications

The Department of Chemistry and Biochemistry at the College of Medicine, Al-Nahrain University, discussed the doctoral dissertation of the student Wiam Fadel Hussein, entitled:

“Assessment of Methylglyoxal, Soluble Receptor for Advanced Glycation End-Products, and Malondialdehyde in Pre-Diabetic and Type 2 Diabetes Mellitus Patients in Relation with Cardiovascular Risk.”

Aim of the Study:

The study aimed to evaluate the serum levels of:

• Methylglyoxal (MG)

• Soluble Receptor for Advanced Glycation End-Products (sRAGE)

• Malondialdehyde (MDA)

in pre-diabetic patients and type 2 diabetes mellitus patients, and to investigate their association with cardiovascular risk, with the objective of exploring their potential role as biomarkers of oxidative stress related to these conditions.

Results:

The study revealed a significant elevation in MG, sRAGE, and MDA levels among type 2 diabetes mellitus patients, both with and without cardiovascular risk, compared to the pre-diabetic group and the control group. These biomarkers were higher in patients at risk of cardiovascular disease.

These findings support the hypothesis that MG, sRAGE, and MDA may serve as promising biomarkers for the early detection of metabolic changes associated with pre-diabetes, type 2 diabetes mellitus, and their cardiovascular complications.

The Discussion Committee:

• Prof. Dr. Mohammed Imran Hamza – Chairman

• Prof. Dr. Raed Jassim Mohammed – Member

• Assist. Prof. Dr. Amal Ismail Ibrahim – Member

• Assist. Prof. Dr. Saba Zuheir Hassan – Member

• Assist. Prof. Dr. Mohammed Abdul Latif Mohammed Ali – Member

• Prof. Dr. Estabraq Abdulrasool Kuiri – Member and Supervisor

• Prof. Dr. Mahmood Shaker Khudair – Member and Supervisor

The dissertation was successfully accepted with a grade of Excellent.

Media and Government Communication Division
College of Medicine – Al-Nahrain University