Master’s Thesis Discussion on the Evaluation of Biomarkers and Their Relation to Fertility in Patients with Polycystic Ovary Syndrome

The Department of Chemistry and Biochemistry at Al-Nahrain College of Medicine discussed the master’s thesis of the student Ahmed Nouri Mousa entitled:

“Assessment of Serum Corin, Prokineticin-1 and Kallistatin Levels in Patients with Polycystic Ovary Syndrome Relation to Fertility.”

The main objective of this study was to evaluate the diagnostic value of serum Corin, Prokineticin-1, and Kallistatin levels in women with polycystic ovary syndrome (PCOS), focusing on comparing these markers between infertile and fertile patients, in addition to exploring the relationship between these biomarkers and key hormonal and biochemical parameters.

The study results showed significantly elevated levels of Corin and Prokineticin-1 in PCOS patients (p < 0.001), while no differences were found in Kallistatin levels among the groups. ROC analysis revealed that Prokineticin-1 had the highest diagnostic accuracy (AUC = 0.721). Moreover, a statistically significant inverse relationship between Corin and Prokineticin-1 levels was observed in infertile PCOS patients, which may play an important role in explaining infertility in women with PCOS.

The discussion committee consisted of:

• Prof. Omar Farouq Abdul Rasheed (Chairman)

• Assist. Prof. Dr. Sahar Abdul Wahab Al-Shaaban (Member)

• Assist. Prof. Dr. Sahar Hisham Abdul Razaq (Member)

• Prof. Dr. Estabraq Abdul Rasool Kuwairi (Member and Supervisor)

• Assist. Prof. Dr. Sarah Abdul Redha Al-Rawaf (Member and Supervisor)

The thesis was accepted with an Excellent grade.

Media and Government Communication Division
College of Medicine – Al-Nahrain University