Ph.D. Dissertation Discusses the Anti-Angiogenic Effect of Corynoline and Hordenine

“The anti-angiogenic activity of Corynoline and Hordenine ex vivo in vivo and in vitro study.”

Both Corynoline and Hordenine demonstrated a clear concentration-dependent inhibitory effect on angiogenesis in the RAR and CAM models, with complete inhibition of microvessel growth observed at concentrations ≥50 μg/ml and IC50 values of approximately 2585 μg/ml for each compound. In cellular studies, both compounds significantly reduced cell viability in a dose-dependent manner in endothelial and cancer cell lines. Corynoline showed slightly higher efficacy in suppressing the growth of HUVEC and MCF7 cells.

Corynoline and Hordenine thus exhibited prominent anti-angiogenic and anti-proliferative activities through inhibition of endothelial cell growth, suppression of the VEGF pathway, and high-affinity interactions with angiogenesis-related receptors. These findings highlight their therapeutic potential as natural anti-angiogenic agents in cancer treatment. Further in-depth studies are recommended to validate these results and clarify the underlying mechanisms.