A Recent Genetic Study Sheds Light on the Association Between Hepcidin and Reproductive Hormones in Women with Beta Thalassemia Major

“Study the Association of Hepcidin Antimicrobial Peptide and Human Hemochromatosis Genes Polymorphism with Serum Hepcidin Ferritin and Fertility Hormones Level in Women with Beta Thalassemia  Major.”

The study included 180 participants, divided into two groups: 90 patients with beta thalassemia major and 90 healthy women as a control group. Several biochemical tests were performed using ELISA to measure the levels of hepcidin, ferritin, and reproductive hormones (LH, FSH, estrogen, and prolactin). Additionally, PCR-RFLP was used to analyze genetic variations in the HAMP and HFE genes.

The researcher highlighted that the findings of this study may open new horizons for early diagnosis and improving the quality of life of women with thalassemia through monitoring biomarkers and genetic factors related to iron regulation and hormonal functions.