اختيار اللغة
وحدة البحوث الطبية العلاقات الثقافية شعبة ضمان الجودة و الأداء الجامعي وحدة التعليم الطبي و تطوير المناهج الدراسية لجنة التعضيد شعبة النشاطات الطلابية
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Evaluation of the changes in iron homeostasis and hepcidin concentration in preeclamptic patients
صبح سالم عبد اللطيف
Authors :
Abstract Background Plasma iron is increased in preeclampsia (PE) in comparison to normal pregnant women. The relation between iron homeostasis and inflammation is hepcidin. Hepcidin is an acute phase reactant protein which has major role in iron hemostasis. Aim of the study: To evaluate serum iron, total iron binding capacity (TIBC), serum ferritin and serum hepcidin levels in preeclamptic pregnant women in relation to non preeclamtic pregnant women, who were not on any iron supplement regimen. Subjects, Materials and Methods: This case control study was conducted on twenty pregnant women in the third trimester of pregnancy suffering from preeclampsia who had not receiving iron supplement nor had blood transfusion within last three months, those patient were attending the obstetric and gynaecology department at (AL-Imamin AL-Kadhmin medical city) between May to August 2013. Along with those patient twenty non preeclamptic pregnant women who were age and gestational age matched were inclded as control group. Moreover any subject presented with active infection,chronic disese, chronic blood loss or twin pregnancy were excluded. A total of 5 ml of venous blood sample was obtained from each patient and control and tested for measurement of Hb, PCV,MCHC by automated device where as, serum of iron and TIBC, ferritin and hepcidin were measured by ELISA technique. Results: The mean level of Hb, PCV, MCHC, serum iron, serum ferritin and serum hepcidin in preeclamptic patients were higher than those of control group (P value of < 0.05).There was a non significant correlation between serum iron and hepcidin in preeclamptic patients (r=0.234, P= 0.32) whereas there was a significant strongly positive correlation between serum iron and hepcidin in the control group (r=0.839, P = 0.003). Conclusions: In preeclamptic patients serum iron concentration is increased in spite of high hepcidin concentration which might indicate a resistance to the iron-decreasing action of hepcidin.

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Iraqi Journal of Hematology ( IJH) May 2016 ; 5 (1): 32-41.