Abstract
Background Vitiligo is the most frequent depigmentation disorder of the skin. None of the therapeutic alternatives is
satisfactory.
Objective To evaluate the effectiveness of systemic Co-enzyme Q10 in patients with vitiligo.
Methods Twelve patients received Co-enzyme Q10 75 mg twice daily compared with 12 patients received placebo
capsule twice daily orally for 8 weeks in the Department of Dermatology, Al-Kadhimiya Teaching
Hospital (November 2011 to march 2012). History of patients was taken and measurement for serum
glutathione (S. GSH) (by Elleman methods), malonialdehyde (S. MDA) (by Stocks and Dormandy
methods) and VASI score at baseline, 4 and 8 weeks interval.
Results No significant difference in S. GSH was found between Co-enzyme and placebo group after 4 and 8
weeks. High significant decrease in S. MDA occurred after 4 and 8 weeks with significant decrease in
VASI were found after 8 weeks.
Conclusion Co-enzyme Q10 may have a role in treatment of vitiligo.
Keywords Co-enzyme Q 10, Vitiligo, Antioxidant.
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2013
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