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Serum Levels of Endotheline-1 and Vascular Endothelial Growth Factor in Chronic Renal FailurePatients Receiving Haemodialysis with Different Etiology
Authors :
The objective of present study was to verify the changes of serum levels of ET-1 and VEGF in Chronic Renal Failure (CRF) Patients undergoing haemodialysis. Sixty five of haemodialysis patients were enrolled in this study and compared with forty healthy subjects. Thirty from these patients were followed up to six months for serial assessment of these biomarkers as well. The results indicated significant elevations of VEGF and ET-1 levels when compared with the control group (P < 0.0001). Also the statistical analysis showed a significant difference in serum levels of VEGF (P < 0.003) according to different causes of chronic renal failure while there was no significant difference in serum levels of ET-1 within different etiology of haemodialysis patients. Moreover there was a significant differences in 3rd and 4th reading of ET-1 and VEGF and a significant differences in 2nd reading of ET-1 level (P < 0.05) when compared to first reading of VEGF and ET-1 through the period of serial assessment. Further, a significant negative correlation were observed for ET-1 and VEGF levels with the GFR of patients(P < 0.05) and a significant positive correlation were demonstrated for the level of ET-1 (P < 0.05) while not with VEGF when they have correlated with the duration of dialysis of patients. The results pointed out that ET-1 and VEGF levels are involved in the pathophysiology of the disease and they were useful in the prediction of the disease earlier to the clinical manifestations of atherosclerotic and cardiovascular disease.

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31-7-2015