ABSTRACT
Aim: This study was designed to investigate the serum levels of vitamins A, C and D in Iraqi patients
with lung cancer as well as in cigarette smokers and to compare them with those of healthy subjects.
Method: Blood samples were collected from 48 lung cancer patients with age ranging between 45-75
years, and from38 male smokers with age ranging between 20-25 years, as well as from 35 health
volunteer subjects with age ranging between 30-65 years.Vitamins (A, C and D) levels were
measured usingisocratic mobile phase HPLC technique with UV-Visible detection. Results: The
results of the current work indicated that the mean values of vitamin A and vitamin C were
significantly lower in serum samples of both smokers (p<0.001) and lung cancer patients(p<0.001)
than in controls. Whereas the concentrations of vitamin D were significantly higher in the serum
samples of both smokers (p<0.001) and lung cancer patients (p<0.05) than in those of healthy
control subjects. Conclusions: According to the present work, it is possible to conclude that adequate
intake of vitamins A and C may have a protective role in occurrence of lung cancer. Also, it can
conclude that exposure to cigarette smoke lead to the depletion of most of the antioxidants in human
serum and thus impair oxidant defense system.
Keywords: Lung cancer, Smoker, Vitamin A, Vitamin C, Vitamin D, HPLC.
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14/11/2015
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