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SERUM CONCENTRATIONS OF VITAMINS A, C AND D IN IRAQI PATIENTS WITH LUNG CANCER AND SMOKERS
Authors :
ABSTRACT Aim: This study was designed to investigate the serum levels of vitamins A, C and D in Iraqi patients with lung cancer as well as in cigarette smokers and to compare them with those of healthy subjects. Method: Blood samples were collected from 48 lung cancer patients with age ranging between 45-75 years, and from38 male smokers with age ranging between 20-25 years, as well as from 35 health volunteer subjects with age ranging between 30-65 years.Vitamins (A, C and D) levels were measured usingisocratic mobile phase HPLC technique with UV-Visible detection. Results: The results of the current work indicated that the mean values of vitamin A and vitamin C were significantly lower in serum samples of both smokers (p<0.001) and lung cancer patients(p<0.001) than in controls. Whereas the concentrations of vitamin D were significantly higher in the serum samples of both smokers (p<0.001) and lung cancer patients (p<0.05) than in those of healthy control subjects. Conclusions: According to the present work, it is possible to conclude that adequate intake of vitamins A and C may have a protective role in occurrence of lung cancer. Also, it can conclude that exposure to cigarette smoke lead to the depletion of most of the antioxidants in human serum and thus impair oxidant defense system. Keywords: Lung cancer, Smoker, Vitamin A, Vitamin C, Vitamin D, HPLC.

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14/11/2015