Angiogenesis, the formation of new blood vessels from pre-existing ones, is enhanced in various pathological
conditions including rheumatoid arthritis, diabetic retinopathy, and cancer development. Angiogenic processes are
regulated by both growth factors, such as vascular endothelial growth factor (VEGF), and adhesion molecules, such as
integrin. Understanding the molecular mechanisms that underlieregulation of angiogenesis especially VEGF function, is
essential for the development of safe and effective antiangiogenic therapies. Thus, current study was aimedto investigate
predictive role of β3 integrin and vascular endothelial growth factor (VEGF) protein expression in colorectal
adenocarcinoma sample from Iraqi patients, through linking its expression with tumor histopathological variables (stage,
grade, grade, andlymph node involvement), by using Immunohistochemicalstaining method. Study done on 35 colorectal
cancer samples and their respective resection margins.Present study demonstrated that, the positive expression rate of
integrin β3 and VEGF in non-tumorcolorectal mucosa (25.33333 ± 1.974842, and 32.4± 1.974842) was significantly lower
than that of the colorectal cancer (CRC)tissue (76.47059± 2.878562, and 79.45714±2.293705; P < 0.05). Moreover, when
CRC samples breakdown according to histopathological variables, In patients of stage C-D, poorly differentiated, and
withlymph node (L.N)invasion, the positive expression rates of integrin β3 were significantly higher than those in patients
of patients with stageA,B, well or moderately differentiated,and without lymphatic metastasis (P < 0.05, P < 0.05, and P <
0.05; P< 0.05, P< 0.05, and P< 0.05), respectively. In conclusion Integrin β3 and VEGF expression can synergistically
enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of colorectal carcinoma. Therefore,
they may be prognostic biomarkers and novel molecular therapeutic targets.
Keyword: Colorectal Cancer, Angiogenesis, VEGF
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October 30, 2013
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