Background: Anabasis articulata, also called Eshnan, Ajremor Berry bearing glasswort, is widely distributed in Syrian,
Algerian, Egyptian and Iraqi desert. Anabasis articulata is broadly used in folk medicine to treat diabetes, fever, eczema and kidney
infections. Objective: to examine the antiangiogenic action of Anabasis articulatain vivo.Subjects and methods: The powder of the
Anabasis articulata stems was sequentially extracted with four solvent types of different polarity.Eggs were gestated for three days, small
whole prepared on the fine pinpoint. The following day, the egg’s sac was penetrated and a small frame was made in the shell. Eggs
were returned to the incubator until day 10 of chick embryo growth, methanol extract was moved to the Chick Embryo Chorioallantoic
Membrane (CAM), and eggs incubated for 72 hours (n = 6); the zone of inhibition was estimated as mean of inhibition area. Functional
groups of the chemicals component private to the extract has been recognized by Fourier transform infrared spectroscopy FT-IR and
Gas chromatography mass spectrometry was utilized to recognize the most likely relevant agent. Results: The results displayed that the
zones of inhibition area range between 7 and 10 mm. FT-IR displayed that some of the recognized functional group may relate to
flavones, coumarins, alkalines, saponins and tannins. Scopoletin, 2-Methoxy-4-vinylphenol, glycine and 1, 2-dimethyl-Piperidine, have
been recognized in methanol extract.Conclusion: the results revealed that the mechanism of anti-angiogenic activity for the methanol
extract of the Anabasis articulata stems may be related to these substances that have the capacity to block the VEGF- receptor, thereby
inhibiting the angiogenesis.
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9 / 2016
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