Background: Bee venom is a complex mixture of proteins, peptides and low molecular components. Nowadays its components have been characterized, the therapeutic application of bee-venom has been well investigated against Gran- negative and Gram-positive bacteria.
Objective: To determine antibacterial activity of bee venom against Multidrug resistant Acinetobacter baumannii locally isolates.
Methods: Bee venom were assessed for their antibacterial activity against four Multidrug resistant Acinetobacter baumannii bacterial strains by using MIC depend on resazurin stain, Well diffusion methods and Reactive Oxygen Species (ROS) generation test
Result: The minimum inhibitory concentration (MIC) of BV were determined with values (31.25 mg/ml) and bee venom have ability to inhibit the growth of MDR Acinetobacter baumannii and may be one of the killing mechanisms by Reactive Oxygen Species (ROS) production which lead to DNA destruction.
Conclusion: bee venom had antibacterial activities against MDR Acinetobacter baumannii which confirms the previous work that suggested that bee venom can inhibit growth and survival of some bacterial strains.
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20/12/2018
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