Assessing the value of diffusion-weighted imaging (DWI) magnetic resonance imaging (MRI) and apparent diffusion coefficient
(ADC) in normal bone marrow (BM) tissue as well as in benign and malignant hematological diseases in comparison with BM
histopathologic report. A cohort cross-sectional study performed from October 2016 till December 2017 in Al-Imamian AlKhadimain Medical City. Forty patients were enrolled and segregated equally into two main groups (benign and malignant
hematological disorders with another 20 healthy volunteers (control group). Hematology data were recorded for all patients in
addition to DWI-MRI and ADC mapping in comparison with bone marrow report for the group of malignant hematological
disease in terms of blast cell percentage. Conventional MRI reveals abnormal signal intensity in 85% of the malignant cases with
different pattern. While 95% of the benign and 100% of control group had normal signal intensity with P value (P = 0.001).
Application of DWI-ADC on three groups of sample reveals a variable range of ADC values which is higher in malignant (225–
875 × 10−6 mm2
\s) than benign (275–600 × 10−6 mm2
\s) and control cases (205–560 × 10−6 mm2
\s) with a cut-off value of
550 × 10−6 mm2
\s. There was a positive correlation between ADC values and blast % in bone marrow histopathological report
with correlation coefficient of 0.75 and P value of 0.05. Both DWI-MRI and ADC are useful in BM assessment. The latter is a
quantitative assay for the diffusion and can reflect a functional assessment in correlation with blast cell percentage.
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SN Comprehensive Clinical Medicine April 2019, https://doi.org/10.1007/s42399-019-00067-4
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