ABSTRACT
The objective of present study was to assess the effect of amlodipine on atherosclerosis via interfering with inflammatory and oxidative pathways. Twenty four local domestic male rabbits were involved in this study. The animals were randomly divided into three groups which include: Group I rabbits fed normal chow (oxiod) diet for 12 weeks. Group II rabbits fed with 1% cholesterol enriched diet. Group III rabbits fed with 1% cholesterol enriched diet together with amlodipine (5 mg/kg once daily before morning feed). Blood samples were collected before zero time and every four weeks of experimental diets for measurement of serum triglycerides, total cholesterol, high density lipoprotein cholesterol, high sensitive C-Reactive Protein, endothelin-1 and intracellular adhesion molecule-1 level. At the end of 12 weeks the aorta was removed for measurement of aortic Malondialdehyde, reduced glutathione and aortic intimal thickness. Amlodipine treatment did show an insignificant effect on lipid parameters compared with induced untreated group (P > 0.05). While it was significantly reduced the elevation in endothelin-1, high sensitive C-Reactive Protein, intracellular adhesion molecule-1 level, aortic MDA and aortic intimal thickness compared with induced untreated group (P < 0.05), and they restore aortic reduced glutathione level (P < 0.05). Amlodipine may decrease atherosclerosis progression in hypercholesterolemic rabbit via interfering with oxidative and inflammatory pathways without affecting lipid parameters.
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30-11-2014
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