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The Wound Healing Activity of (Rue) Ruta graveolens L. Methanolic Extract in Rats
Authors :
ABSTRACT This study was designed to evaluation the wound healing activity of Rutagraveolens L. methanolic extract in rats as a medicinal plant grown in Iraq. The dried powder of the leaves (360 gm) was extracted by adding 30gm in each of the twelve flasks with 200ml of methanol. Extract was concentrated using a rotary evaporator under vacuum and then dried. Eighteen Sprague Dawley (SD) rats were used in this study; the rats were divided into three groups each composed of six male rats of almost same weight. All rats were injured at their Para vertebral, straight incision of 2 cm length was made through the entire thickness of the skin, on other side of the vertebral column with the help of a sharp. First group treated with 5% methanol extract ones daily for three days, second group received nothing but the vehicle vaseline used as a paste for the extract in the first group and considered as negative control, third group treated with sulphasalaz in which considered as positive control. The results showed that methanol extract of R. Graveolens significantly healed the wound in comparison to the positive and negative controls. The wound healing that methanol extract showed may be due to the plant active constituents. The alkaloids and terpines that R. graveolens contain have important roles in wound healing.

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30-11-2014