Background: In medicine, a 25-hydroxy vitamin D (calcidiol) blood test is used to determine how
much vitamin D is in the body. The blood concentration of calcidiol is considered the best indicator
of vitamin D status. It is the most sensitive measure, though experts have called for improved
standardization and reproducibility across different laboratories , the normal range of calcidiol is
30.0 to 74.0 ng/mL. Objective: To evaluate vitamin D3 in iraqi patients with ankylosingspondylitis
,and represent its affect on disease activity. Material and methods: Eighty five AS patients are
enrolled in this study with a mean age of 36 ± 41 years & age range from 16-56 years , mean
duration equal to 12.08. Results: There was a slightly non significant increase of mean serum level
of vitamin D3 in G2 & G3 ( 24.26 ± 16.51 ng/ml , p = 0.914 , 24.28 ± 16.16 ng/ml , p = 0.912 )
respectively compared with it in G1 (23.79 ± 14.00 ng/ml ). This represented in table 3.2 . There is a
highly significant decrease of mean ± SD of BASFI & BASDAI in G2 & G3 (5.87 ± 1.13 , 3.34 ± 0.585, P
< 0.001 , 3.34 ± 0.78 , 1.35 ± 0.66 , P < 0.001) respectively compared in G1 (7.91 ± 0.78 , 5.51 ± 0.79)
. Conclusion: Serum vitamin D levels can decrease in AS patients due to both nutritional deficiency
and inadequate exposure to sunlight, or for etiopathogenetic reasons. They also led us to the
conslusion that insufficiency of vitamin D may cause increased disease activity and fatigue, and
decreased functional capacity and quality of life.
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25/10/2014
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