The underlying pathology of the vast majority of diabetic polyneuropathies is axonal degeneration. F wave study is one of the most sensitive indices of the severity of neuropathy.
To test the validity of different F wave parameters including F minimum latency, F wave index and F Jitter in the diagnosis of diabetic axonal peripheral neuropathy.
Eighty type 2 diabetics aged 52.57±5.62 years with disease duration of 1 to 18 years and 90 age-matched healthy volunteers serve as the control group. Both groups were submitted to medical history, clinical neurological examination, and electrophysiological tests of both upper and lower limbs.
Tibial and ulnar F wave latencies were significantly prolonged in diabetic patients (p < 0.001). Tibial F index for male patients shows a significantly lower value as compared to the control group. Ulnar F wave latency was 76.7% sensitive and 89.3% specific in female patients while tibial F wave latency was 80% sensitive and 81.3% specific in male patients.
F wave is a precise parameter in detecting diabetic axonal peripheral neuropathy. Minimal F-wave latency is more sensitive than both F index and F Jitter in the diagnosis of axonal neuropathy in diabetic patients.
DM, Axonal neuropathy, Ulnar, Tibial, F-wave latency, F-jitter, F-index
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