Correlation of Lactate Dehydrogenase (LDH) activity, D-Dimer and Severity in a sample of COVID-19 patients in Iraq
حيدر عبد الحميد رشيد
Authors : Ali Y. Salem Dr.Raid J. Al- Timimi Dr. Haider Abdulhameed Alqaraghuli
Abstract Subject: The coronavirus pandemic, which began in 2019, is a global outbreak of coronavirus disease. The World Health Organization (WHO) also classified Severe Acute Respiratory Syndrome (SARS) as a new coronavirus (SARS-CoV-2). Wuhan, China, was the first place in December 2019 when the pandemic was found. LDH levels were related with a six-fold increase in the risk of developing severe COVID-19 disease. Objective of the study :Estimation of enzyme activity of Lactate Dehydrogenase enzyme (LDH) and d-dimer in patients with COVID-19 to estimate the behavior of enzyme during the period of disease. Correlation of enzyme activity Lactate Dehydrogenase (LDH)with d-dimer. More crucially, elevated LDH was related with a 16-fold increase in the risk of death. Abnormal coagulation function, including elevated D-dimer, has been demonstrated to be more common in deceased patients with COVID-19, and increasing odds of in-hospital death was associated with D-dimer greater than 1 μg/ml. The current study aimed to investigate serum levels of LDH and d- dimer in severity of COVID-19 patients, and to clarify the correlation of these parameters with disease severity Material and method : This study included (48) patients with COVID-19 in severity (confirmed by polymerase chain reaction). COVID-19 patients showed a significant elevation in the levels of all parameters, we concluded a proportional correlation between the aforementioned parameters and COVID-19 suggesting the uses of these tests to the diagnosis of severe cases. Results :This study showed high correlation between activity of lactate dehydrogenase (LDH) and disease progression and severity in patients with COVID-19. Also the study showed high correlation between D-dimer and disease progression and severity in patients with COVI19. Conclusion :There is correlation between lactate dehydrogenase (LDH)level and D- dimer level in later on during disease Progression. But not and the time of hospitalization. Keywords : COVID-19 , Severe Acute Respiratory Syndrome (SARS) and LDH

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