Abstract Subject: The coronavirus pandemic, which began in 2019, is a global outbreak of coronavirus disease. The World
Health Organization (WHO) also classified Severe Acute Respiratory Syndrome (SARS) as a new coronavirus
(SARS-CoV-2). Wuhan, China, was the first place in December 2019 when the pandemic was found. LDH levels
were related with a six-fold increase in the risk of developing severe COVID-19 disease.
Objective of the study :Estimation of enzyme activity of Lactate Dehydrogenase enzyme (LDH) and d-dimer in
patients with COVID-19 to estimate the behavior of enzyme during the period of disease. Correlation of enzyme
activity Lactate Dehydrogenase (LDH)with d-dimer. More crucially, elevated LDH was related with a 16-fold
increase in the risk of death. Abnormal coagulation function, including elevated D-dimer, has been demonstrated
to be more common in deceased patients with COVID-19, and increasing odds of in-hospital death was associated
with D-dimer greater than 1 μg/ml. The current study aimed to investigate serum levels of LDH and d- dimer in
severity of COVID-19 patients, and to clarify the correlation of these parameters with disease severity
Material and method : This study included (48) patients with COVID-19 in severity (confirmed by polymerase
chain reaction). COVID-19 patients showed a significant elevation in the levels of all parameters, we concluded a
proportional correlation between the aforementioned parameters and COVID-19 suggesting the uses of these tests
to the diagnosis of severe cases.
Results :This study showed high correlation between activity of lactate dehydrogenase (LDH) and disease
progression and severity in patients with COVID-19. Also the study showed high correlation between D-dimer and
disease progression and severity in patients with COVI19.
Conclusion :There is correlation between lactate dehydrogenase (LDH)level and D- dimer level in later on during
disease Progression. But not and the time of hospitalization.
Keywords : COVID-19 , Severe Acute Respiratory Syndrome (SARS) and LDH
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1/8/2021
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