Oxidative stress represents an imbalance between reactive oxygen species (ROS) and cellular mechanisms for detoxifying the
reactive intermediates or repairing the resulting damage, in this study oxidative stress was evaluated by anti-Mda antibodies that
directed against malondialdhyde (Mda) in different placental regions (cord insertion, central, and peripheral) in different age groups
(preterm, term, and postdate), and correlated with syncytial apoptosis expressed as syncytial knots count that stained with Tunel
stain. A significant variation was found in anti-Mda antibody among age groups in all placental regions and syncytial knots count in
peripheral region only at p≤0.05, with a highly significant positive correlation between syncytial knot counts and oxidative stress in
peripheral region at termat r.0.811, and significant negative correlation at r.0.003 in postdate group in peripheral region. We
conclude that oxidative stress play a major role in syncytial apoptosis as formation of syncytial knots that later on detached and
liberated into the maternal circulation, this effect is more pronounced in the peripheral region of the placenta due to its distance
from umbilical cord blood supply.
(FULL ARTICLE LINK) Read more ...
4-1-2015
|
|
|