Polycystic ovary syndrome (PCOS) is still a matter of research looking for the true pathogenesis of this enigmatic syndrome.
Although the majority of cases are familial, genetic studies have failed so far to identify the specific genes involved. The
presentations of PCOS are heterogeneous and may change throughout the lifespan, starting from adolescence to postmenopausal age, and may have health impaction later in life. Omentin-1 is a fat depot-specific secretory protein produced
by visceral stromal vascular cells. Recent studies showed that omentin-1 is correlated inversely with obesity and insulin
resistance.
Objective To assess the serum omentin-1 concentration in PCOS women and the effect of metformin on omentin-1 level, to evaluate
the role of omentin-1 on insulin resistance and hyperandrogenemia in PCOS women and to look for the correlation of
omentin-1 with body mass index (BMI) in PCOS women.
Methods Eighty women involved in this study; 40 women with PCOS diagnosed according to Rotterdam ESHRE/ASRMS 2003 criteria
and 40 apparently healthy women considered as the control group. The participants were allocated into six groups: “10
obese women with PCOS (BMI ≥30 kg/m2
, without metformin treatment)”. “10 obese women with PCOS (BMI ≥30 kg/m2
,
taking metformin)”. “10 non-obese women with PCOS (BMI <30 kg/m2
, without metformin treatment)”. “10 non-obese
women with PCOS (BMI <30 kg/m2
, taking metformin)”. “20 obese controls and 20 non-obese controls. Blood samples were
taken from them for estimation of fasting blood glucose, insulin and omentin-1 levels. Hirsutism score was also evaluated
according to Ferriman–Gallwey score.
Results There was a significant increase in omentin-1 in non-obese PCOS (taking metformin) (3.02±0.71) compared to obese PCOS
(taking metformin) (1.59±1.48) (P value = 0.0132) and in PCO non-obese (taking metformin) (3.02±0.71) compared with
control non-obese (1.96±1.65) (P value = 0.121). No significant correlation was found between serum omentin-1 level and
insulin resistance as well as with hyperandrogenemia in any of the six study groups.
Conclusion Omentin-1 is found to be inversely related to body weight in PCOS women. Serum omentin-1 level has no effect on insulin
resistance and hyperandrogenism states
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2017
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